It's not necessarily the case with every rattle can primer or paint, but sometimes the solvents in a catalyzed material like a 2k primer or sealer, or even solvent base coats or clear coat may end up attacking the non-catalyzed material (spray can paint). You would end up with lifting and bubbling and all kinds of problems that would make you start over. So, as a general rule, no they are not compatible. It's best to stick with automotive paints wherever possible when working on the exterior of your car.
Eastwood Technical Department